血管紧张素转换酶与心血管疾病的药物研发。
Angiotensin-converting enzymes and drug discovery in cardiovascular diseases.
机构信息
Department of Human Sport Science, Beijing Sport University, Beijing 100084, China.
出版信息
Drug Discov Today. 2010 May;15(9-10):332-41. doi: 10.1016/j.drudis.2010.02.003. Epub 2010 Feb 17.
Abstract
Angiotensin-converting enzyme (ACE) is a major target in the treatment of cardiovascular diseases (CVDs). In addition to ACE, ACE2 - which is a homolog of ACE and promotes the degradation of angiotensin II (Ang II) to Ang (1-7) - has been recognized recently as a potential therapeutic target in the management of CVDs. This article reviews different metabolic pathways of ACE and ACE2 (Ang I-Ang II-AT1 receptors and Ang I-Ang (1-7)-Mas receptors) in the regulation of cardiovascular function and their potential in new drug development in the therapy of CVDs. In addition, recent progress in the study of angiotensin and ACE in fetal origins of CVD, which might present an interesting field in perinatal medicine and preventive medicine, is briefly summarized.
摘要
血管紧张素转换酶（ACE）是治疗心血管疾病（CVDs）的主要靶点。除 ACE 外，ACE2 - ACE 的同源物，可促进血管紧张素 II（Ang II）降解为 Ang（1-7）- 最近也被认为是 CVDs 管理中潜在的治疗靶点。本文综述了 ACE 和 ACE2（Ang I-Ang II-AT1 受体和 Ang I-Ang（1-7）-Mas 受体）在心血管功能调节中的不同代谢途径及其在 CVDs 治疗中新药开发中的潜力。此外，还简要总结了血管紧张素和 ACE 在心血管疾病胎儿起源中的最新研究进展，这可能是围产医学和预防医学中一个有趣的领域。
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