Novosibirsk State University, Novosibirsk, Russia.
Cell Immunol. 2010;262(2):120-6. doi: 10.1016/j.cellimm.2010.01.005. Epub 2010 Feb 1.
Exogenous allogenic DNA as nucleosome-free fragments reaches main cellular compartments (cytoplasm, nucleus) of human dendritic cells and deposits in the nuclear interchromosomal space without visibly changing in linear size. The presence of such allogenic fragmented DNA in medium in which human dendritic cells are cultured produces an enhancement of their allostimulatory activity. This enhancement is comparable to that produced by the standard maturation stimulus lipopolysaccharide Escherichia coli.
外源性同种异体 DNA 作为无核小体片段到达人树突状细胞的主要细胞区室（细胞质、细胞核），并沉积在核染色质间空间，而在线性尺寸上没有明显变化。在培养人树突状细胞的培养基中存在这种同种异体的片段化 DNA 会增强其抗原提呈活性。这种增强作用与标准成熟刺激物大肠杆菌脂多糖产生的增强作用相当。
