太赫兹场存在下的DNA呼吸动力学
DNA Breathing Dynamics in the Presence of a Terahertz Field.
作者信息
Alexandrov B S, Gelev V, Bishop A R, Usheva A, Rasmussen K Ø
机构信息
Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545.
出版信息
Phys Lett A. 2010 Feb 22;374(10):1214. doi: 10.1016/j.physleta.2009.12.077.
Abstract
We consider the influence of a terahertz field on the breathing dynamics of double-stranded DNA. We model the spontaneous formation of spatially localized openings of a damped and driven DNA chain, and find that linear instabilities lead to dynamic dimerization, while true local strand separations require a threshold amplitude mechanism. Based on our results we argue that a specific terahertz radiation exposure may significantly affect the natural dynamics of DNA, and thereby influence intricate molecular processes involved in gene expression and DNA replication.
摘要
我们考虑太赫兹场对双链DNA呼吸动力学的影响。我们对受阻尼和驱动的DNA链中空间局部开口的自发形成进行建模，发现线性不稳定性会导致动态二聚化，而真正的局部链分离需要阈值振幅机制。基于我们的结果，我们认为特定的太赫兹辐射暴露可能会显著影响DNA的自然动力学，从而影响基因表达和DNA复制中涉及的复杂分子过程。
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