Department of Surgery, The Second Affiliated Hospital, College of Medicine, Cancer Institute, Zhejiang University, 88# Jiefang Road, Hangzhou 310009, People's Republic of China.
J Cancer Res Clin Oncol. 2010 Nov;136(11):1627-31. doi: 10.1007/s00432-010-0820-0. Epub 2010 Feb 20.
The relationship between diabetes and pancreatic cancer has been established by more than several decades of research. However, serum levels of CEA and CA 19-9 in diabetic pancreatic cancer has not been shown.
Preoperative serum levels of CEA and CA 19-9 and clinicopathological characteristics were retrospectively analyzed in 79 with or 229 without diabetes in pancreatic ductal adenocarcinoma (PDA) patients.
Of the 308 PDA patients enrolled, 79 (25.6%) patients had diabetes. The percentage of new-onset diabetes (i.e. <24 months in duration) was 57% (45/79) in PDA patients coupled with diabetes. Among diabetic PDA patients, mean total bilirubin and fasting blood glucose significantly increased in comparison with control groups (8.54 ± 14.88 vs. 4.16 ± 6.12; 170.22 ± 106.96 vs. 95.84 ± 15.76; P < 0.05). No significant differences were observed in mean levels of serum CA 19-9 and CEA levels between two groups. However, when the value of CEA and CA 19-9 was analyzed as a dichotomous variable, elevated CEA (≥5 ng/ml) and CA 19-9 (≥500 U/ml) levels were strongly correlated with the presence of diabetes in PDA patients.
Elevated CEA (≥5 ng/ml) and CA19-9 (≥500 U/ml) levels have an association with diabetic pancreatic cancer. New-onset diabetes combined with higher CA 19-9 and/or CEA might be regarded as a useful tool to screen early pancreatic cancer.
糖尿病与胰腺癌之间的关系已经被几十年的研究证实。然而，在糖尿病合并胰腺癌患者中，尚未明确其癌胚抗原（CEA）和糖类抗原 19-9（CA 19-9）的血清水平。
回顾性分析了 79 例糖尿病合并和 229 例非糖尿病胰腺导管腺癌（PDA）患者的术前 CEA 和 CA 19-9 血清水平及临床病理特征。
在纳入的 308 例 PDA 患者中，79 例（25.6%）患者患有糖尿病。在患有糖尿病的 PDA 患者中，新发糖尿病（即病程<24 个月）的比例为 57%（45/79）。与对照组相比，糖尿病合并 PDA 患者的总胆红素和空腹血糖水平显著升高（8.54±14.88 vs. 4.16±6.12；170.22±106.96 vs. 95.84±15.76；P<0.05）。两组间血清 CA 19-9 和 CEA 水平的平均值无显著差异。然而，当 CEA 和 CA 19-9 值被分析为二分类变量时，升高的 CEA（≥5ng/ml）和 CA 19-9（≥500U/ml）水平与 PDA 患者糖尿病的发生密切相关。
升高的 CEA（≥5ng/ml）和 CA19-9（≥500U/ml）水平与糖尿病合并胰腺癌相关。新发糖尿病合并较高的 CA 19-9 和/或 CEA 可能被视为筛查早期胰腺癌的有用工具。
