Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
J Dermatol. 2010 Jan;37(1):81-4. doi: 10.1111/j.1346-8138.2009.00751.x.
We report a 4-year-old girl presenting with progressive linear scleroderma affecting the right leg. Biopsy specimen disclosed typical histopathological findings of localized scleroderma. Right leg magnetic resonance imaging (MRI) showed high signal areas on T(2)-weighted images on the subcutaneous fatty tissue, muscles and bone marrow, suggesting that skin inflammation extended to the bone marrow. Oral corticosteroid therapy was instituted with improvement of both skin sclerosis and MRI findings. Our observations suggest that MRI examination should be considered in patients with localized scleroderma to evaluate the extension of the inflammation.
我们报告了一例 4 岁女孩，其右下肢出现进行性线状硬皮病。活检标本显示局限性硬皮病的典型组织病理学发现。右下肢磁共振成像（MRI）显示皮下脂肪组织、肌肉和骨髓的 T2 加权图像上有高信号区，提示皮肤炎症已扩展到骨髓。给予口服皮质类固醇治疗后，皮肤硬化和 MRI 发现均有改善。我们的观察结果表明，对于局限性硬皮病患者，应考虑进行 MRI 检查以评估炎症的扩展。
