JMF's ACPM Med. College, Dhule, India.
Indian J Pharmacol. 2009 Feb;41(1):9-14. doi: 10.4103/0253-7613.48882.
To compare three treatment modalities in scabies for safety, efficacy, and economy in a local population of Nagpur.
This was a prospective, randomized, comparative clinical trial conducted in 103 participants, randomly allocated to three groups. First group received benzyl benzoate (BB) 25% lotion, second group received permethrin 5% cream, whereas third group received tablet ivermectin 200 mug/kg as a single dose. The participants were recalled after one week for follow-up evaluation. If there were no signs of cure, the same intervention was repeated. The participants were followed up for two weeks for cure rate, adverse drug reaction (ADR) monitoring, and postintervention observation. The follow-up was stopped after two weeks.
Fischer's exact test using Graph pad Instat v 3.05.
Ivermectin showed 100% cure rate after two weeks of treatment. Permethrin decreased pruritus by 76% at the end of one week and had significantly better cure rate than ivermectin. At the end of two weeks treatment, this finding was reversed, that is, cure rate in ivermectin group was 100%. For cost-effectiveness analysis, treatment regimens were formulated hypothetically for comparison from Markov population tree for decision analysis. It was found that BB and ivermectin each consecutively for two weeks were most cost effective regimens giving complete cure in four weeks, while ivermectin was the fastest regimen giving the same results in two weeks.
Benzyl benzoate as first line intervention and ivermectin in the remaining gave best cost-effective results in the study patients of scabies.
在印度那格浦尔的本地人群中，比较三种疥疮治疗方式的安全性、疗效和经济性。
这是一项前瞻性、随机、对照临床试验，纳入了 103 名参与者，随机分为三组。第一组接受苯甲醇苯甲酸酯（BB）25%洗剂，第二组接受 5%扑灭司林乳膏，第三组接受伊维菌素 200 微克/千克片剂，单次给药。一周后对参与者进行随访评估。如果没有治愈迹象，则重复相同的干预措施。对参与者进行为期两周的治愈率、药物不良反应（ADR）监测和干预后观察。两周后随访结束。
Graph pad Instat v 3.05 中的 Fisher 确切检验。
伊维菌素在治疗两周后显示出 100%的治愈率。扑灭司林乳膏在一周末可将瘙痒减少 76%，其治愈率明显优于伊维菌素。在两周的治疗结束时，这一发现发生了逆转，即伊维菌素组的治愈率为 100%。对于成本效益分析，从马尔可夫人群树为决策分析制定了假设的治疗方案进行比较。结果发现，BB 和伊维菌素各连续两周是最具成本效益的方案，可在四周内实现完全治愈，而伊维菌素是最快的方案，可在两周内达到相同的效果。
苯甲醇苯甲酸酯作为一线干预措施，伊维菌素作为后续治疗，在本研究的疥疮患者中可获得最佳的成本效益结果。
