Centre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, Australia.
Public Service Research Group, School of Business UNSW Canberra, Canberra, Australia.
PLoS Negl Trop Dis. 2019 Mar 8;13(3):e0007182. doi: 10.1371/journal.pntd.0007182. eCollection 2019 Mar.
Scabies is a common dermatological condition, affecting more than 130 million people at any time. To evaluate and/or predict the effectiveness and cost-effectiveness of scabies interventions, disease transmission modelling can be used.
To review published scabies models and data to inform the design of a comprehensive scabies transmission modelling framework to evaluate the cost-effectiveness of scabies interventions.
Systematic literature search in PubMed, Medline, Embase, CINAHL, and the Cochrane Library identified scabies studies published since the year 2000. Selected papers included modelling studies and studies on the life cycle of scabies mites, patient quality of life and resource use. Reference lists of reviews were used to identify any papers missed through the search strategy. Strengths and limitations of identified scabies models were evaluated and used to design a modelling framework. Potential model inputs were identified and discussed.
Four scabies models were published: a Markov decision tree, two compartmental models, and an agent-based, network-dependent Monte Carlo model. None of the models specifically addressed crusted scabies, which is associated with high morbidity, mortality, and increased transmission. There is a lack of reliable, comprehensive information about scabies biology and the impact this disease has on patients and society.
Clinicians and health economists working in the field of scabies are encouraged to use the current review to inform disease transmission modelling and economic evaluations on interventions against scabies.
疥疮是一种常见的皮肤病，任何时候都有超过 1.3 亿人受到影响。为了评估和/或预测疥疮干预措施的有效性和成本效益，可以使用疾病传播模型。
综述已发表的疥疮模型和数据，为综合疥疮传播建模框架的设计提供信息，以评估疥疮干预措施的成本效益。
在 PubMed、Medline、Embase、CINAHL 和 Cochrane Library 中进行系统文献检索，以确定自 2000 年以来发表的疥疮研究。选定的论文包括建模研究和疥疮螨虫生命周期、患者生活质量和资源利用的研究。综述的参考文献用于确定通过搜索策略遗漏的任何论文。评估并利用已确定的疥疮模型的优缺点来设计建模框架。确定了潜在的模型输入并进行了讨论。
发表了 4 种疥疮模型：马尔可夫决策树、2 种房室模型和基于代理的、网络依赖的蒙特卡罗模型。这些模型都没有专门针对结痂性疥疮，因为结痂性疥疮与高发病率、死亡率和增加的传播有关。关于疥疮生物学以及这种疾病对患者和社会的影响，缺乏可靠、全面的信息。
鼓励从事疥疮领域的临床医生和卫生经济学家使用本综述来为针对疥疮的干预措施的疾病传播建模和经济评估提供信息。
