The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Mol Sci. 2022 Jul 24;23(15):8158. doi: 10.3390/ijms23158158.
Recent studies have demonstrated that immunological disease progression is closely related to abnormal function of the central nervous system (CNS). Rheumatoid arthritis (RA) is a chronic, inflammatory synovitis-based systemic immune disease of unknown etiology. In addition to joint pathological damage, RA has been linked to neuropsychiatric comorbidities, including depression, schizophrenia, and anxiety, increasing the risk of neurodegenerative diseases in life. Immune cells and their secreted immune factors will stimulate the peripheral and central neuronal systems that regulate innate and adaptive immunity. The understanding of autoimmune diseases has largely advanced insights into the molecular mechanisms of neuroimmune interaction. Here, we review our current understanding of CNS comorbidities and potential physiological mechanisms in patients with RA, with a focus on the complex and diverse regulation of mood and distinct patterns of peripheral immune activation in patients with rheumatoid arthritis. And in our review, we also discussed the role that has been played by peripheral neurons and CNS in terms of neuron mechanisms in RA immune challenges, and the related neuron-immune crosstalk.
最近的研究表明，免疫性疾病的进展与中枢神经系统（CNS）的异常功能密切相关。类风湿关节炎（RA）是一种病因不明的慢性、炎症性滑膜炎为基础的系统性自身免疫性疾病。除了关节病理损伤外，RA 还与神经精神合并症有关，包括抑郁、精神分裂症和焦虑症，这增加了生活中神经退行性疾病的风险。免疫细胞及其分泌的免疫因子会刺激调节先天和适应性免疫的外周和中枢神经元系统。对自身免疫性疾病的认识在很大程度上促进了神经免疫相互作用的分子机制的研究。在这里，我们综述了我们目前对 RA 患者中枢神经系统合并症和潜在生理机制的理解，重点关注情绪的复杂和多样调节以及类风湿关节炎患者外周免疫激活的不同模式。在我们的综述中，我们还讨论了外周神经元和中枢神经系统在 RA 免疫挑战中神经元机制以及相关的神经元-免疫相互作用中所起的作用。
