三环生物碱核心结构通过环三聚化偶联分子内亲核取代反应构建。
Tricyclic alkaloid core structures assembled by a cyclotrimerization-coupled intramolecular nucleophilic substitution reaction.
机构信息
North Carolina State University, Department of Chemistry, Raleigh, North Carolina 27695-8204, USA.
出版信息
Org Lett. 2010 Mar 19;12(6):1288-91. doi: 10.1021/ol100177u.
PMID:20178343
Abstract
A facile approach to tricyclic alkaloid core structures was developed by sequencing a pyridine-forming [2 + 2 + 2] cyclotrimerization reaction with an intramolecular nucleophilic substitution. This methodology enabled the facile assembly of the spiroindolinone framework of citrinadins A and B, and cyclopiamine B.
摘要
通过序列吡啶形成的[2+2+2]环三聚反应与分子内亲核取代反应，开发了一种构建三环生物碱核心结构的简便方法。该方法能够简便地构建 citrinadins A 和 B 以及 cyclopiamine B 的螺吲哚啉酮骨架。
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