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一种潜在的醋酸生育酚负载的棕榈油酯-水纳米乳剂，用于纳米化妆品。

A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals.

机构信息

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

出版信息

J Nanobiotechnology. 2010 Feb 23;8:4. doi: 10.1186/1477-3155-8-4.

DOI:10.1186/1477-3155-8-4
PMID:20178581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2839968/
Abstract

BACKGROUND

Cosmeceuticals are cosmetic-pharmaceutical hybrids intended to enhance health and beauty of the skin. Nanocosmeceuticals use nano-sized system for the delivery of active ingredients to the targeted cells for better penetration. In this work, nanoemulsion from palm oil esters was developed as a delivery system to produce nanocosmeceuticals. The stability of the resulting formulation was tested using various methods. In addition, the effect of components i.e. Vitamin E and Pluronic F-68 on the formulation was also studied.

RESULTS

Both vitamin E and Pluronic F-68 were found to co-emulsify and co-stabilized the formulations. The best formulation was found to be the one having the composition of 10% Palm Oil Esters (POEs), 10% vitamin E, 24% Tween 80, 2.4% Pluronic F-68 and 53.6% deionised water. Those compositions are considered to be the best as a nanocosmeceutical product due to the small particle size (94.21 nm), low occurrence of Ostwald ripening and stable at different storing temperatures (5, 25 and 45 degrees C) for four weeks.

CONCLUSIONS

Palm oil esters-in-water nanoemulsions loaded with vitamin E was successfully formulated and has the potential for the use as nanocosmeceuticals.

摘要

背景

化妆品-药物混合体，即所谓的“药妆”，旨在增强皮肤的健康和美丽。纳米药妆利用纳米尺寸的系统将活性成分递送至靶向细胞，以实现更好的穿透效果。在这项工作中，开发了一种来自棕榈油酯的纳米乳液作为递送系统，以生产纳米药妆。使用各种方法测试了所得配方的稳定性。此外，还研究了成分（如维生素 E 和 Pluronic F-68）对配方的影响。

结果

发现维生素 E 和 Pluronic F-68 都可以共同乳化并稳定配方。发现最佳配方是含有 10%棕榈油酯（POEs）、10%维生素 E、24%吐温 80、2.4% Pluronic F-68 和 53.6%去离子水的配方。这些成分被认为是最佳的纳米药妆产品，因为其粒径小（94.21nm）、奥斯特瓦尔德熟化发生率低，并且在不同储存温度（5、25 和 45°C）下稳定，持续四周。

结论

成功制备了负载维生素 E 的棕榈油酯水基纳米乳液，具有作为纳米药妆的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/73a3af3e5674/1477-3155-8-4-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/0191dba6b313/1477-3155-8-4-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/878162923da9/1477-3155-8-4-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/73a3af3e5674/1477-3155-8-4-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/0191dba6b313/1477-3155-8-4-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/97826ed1a33d/1477-3155-8-4-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/e4038d5a0edd/1477-3155-8-4-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/79f074af52f8/1477-3155-8-4-4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/53581eb171e9/1477-3155-8-4-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/621a42f0402d/1477-3155-8-4-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866f/2839968/d1518fccf907/1477-3155-8-4-8.jpg
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