抗拒逮捕：复发性恶性脑胶质瘤中血管生成向血管发生的转变。
Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas.
机构信息
Pediatric Brain Tumor Research and Children's Cancer and Blood Foundation Laboratories, Champalimaud Metastasis Programme, New York, New York, USA.
出版信息
J Clin Invest. 2010 Mar;120(3):663-7. doi: 10.1172/JCI42345. Epub 2010 Feb 22.
Abstract
The cellular and molecular events that initiate and promote malignant glioma development are not completely understood. The treatment modalities designed to promote its demise are all ultimately ineffective, leading to disease progression. In this issue of the JCI, Kioi et al. demonstrate that vasculogenesis and angiogenesis potentially play distinct roles in the etiology of primary and recurrent malignant gliomas, suggesting that patient therapy should perhaps be tailored specifically against the predominant vasculature pathway at a given specific stage of gliomagenesis.
摘要
细胞和分子事件的启动和促进恶性脑胶质瘤的发展尚不完全清楚。旨在促进其死亡的治疗方式最终都是无效的，导致疾病的进展。在本期的 JCI 中，Kioi 等人表明血管生成和血管生成可能在原发性和复发性恶性脑胶质瘤的病因中发挥不同的作用，这表明患者的治疗应该根据特定的脑胶质瘤发生阶段针对占主导地位的血管途径进行具体定制。
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本文引用的文献
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