Lattes R, Jacob N, de la Fuente J, Fragale G, Massari P
Department of Transplantation, Infectious Disease Section, Instituto de Nefrología, Cabello, Buenos Aires, Argentina.
Transpl Infect Dis. 2010 Apr;12(2):169-72. doi: 10.1111/j.1399-3062.2010.00494.x. Epub 2010 Feb 17.
One of the concerns regarding the pandemic of novel influenza A/H1N1 virus is its potential to hamper transplant programs if the decision is made that organs from donors with influenza A/H1N1 should not be used. Evidence of transmissibility through organ transplantation is speculative at best. We report the outcome of 2 kidney transplant recipients who received kidneys from the same deceased donor, in whom the diagnosis of infection by the novel virus became available only after engraftment. The donor also had received a complete course of antiviral treatment before donation. The recipients were transplanted at 2 different facilities and were managed differently. Neither recipient developed flu syndrome, and both had an uneventful outcome. It is possible to speculate that kidneys from donors who have had confirmed influenza A/H1N1 and who have received antiviral treatment can be safely used in transplantation.
关于甲型H1N1新型流感病毒大流行，一个令人担忧的问题是，如果决定不使用甲型H1N1流感病毒感染者捐赠的器官，那么这有可能阻碍移植项目。通过器官移植传播病毒的证据充其量只是推测性的。我们报告了2例肾移植受者的情况，他们接受了来自同一位已故捐赠者的肾脏，在植入后才确诊该新型病毒感染。捐赠者在捐赠前也接受了完整疗程的抗病毒治疗。这两名受者在不同的机构接受移植，管理方式也不同。两名受者均未出现流感综合征，且结局均平稳。可以推测，已确诊感染甲型H1N1流感病毒且接受过抗病毒治疗的捐赠者的肾脏可安全用于移植。
