来自耐盐杂色曲霉的异刺青霉素型生物碱，杂色菌素A-L。

Isoechinulin-type alkaloids, variecolorins A-L, from halotolerant Aspergillus variecolor.

作者信息

Wang Wen-Liang, Lu Zhen-Yu, Tao Hong-Wen, Zhu Tian-Jiao, Fang Yu-Chun, Gu Qian-Qun, Zhu Wei-Ming

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

出版信息

J Nat Prod. 2007 Oct;70(10):1558-64. doi: 10.1021/np070208z. Epub 2007 Sep 27.

DOI:10.1021/np070208z

PMID:17896816

Abstract

Twelve new compounds, variecolorins A-L ( 1- 12), together with eleven known analogues ( 13- 23) were isolated from the broth of a halotolerant fungus, Aspergillus variecolor. The structures of compounds 1- 12 were determined by chemical and spectroscopic methods. Compounds 1- 11, 13- 15, and 20- 23 exhibited weak radical scavenging activity against DPPH, with IC 50 values from 43 to 103 microM. The new compounds 1- 12 all were essentially nontoxic against the P388, HL-60, BEL-7402, and A-549 cell lines with IC 50 values from 70 to 260 microM.

摘要

从耐盐真菌杂色曲霉的发酵液中分离出12种新化合物，即杂色菌素A-L（1-12），以及11种已知类似物（13-23）。通过化学和光谱方法确定了化合物1-12的结构。化合物1-11、13-15和20-23对DPPH表现出较弱的自由基清除活性，IC50值为43至103微摩尔。新化合物1-12对P388、HL-60、BEL-7402和A-549细胞系基本无毒，IC50值为70至260微摩尔。