定义自闭症儿童的睡眠表型。
Defining the sleep phenotype in children with autism.
作者信息
Goldman Suzanne E, Surdyka Kyla, Cuevas Ramon, Adkins Karen, Wang Lily, Malow Beth A
机构信息
Sleep Disorders Division, Department of Neurology and Kennedy Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
出版信息
Dev Neuropsychol. 2009;34(5):560-73. doi: 10.1080/87565640903133509.
Abstract
Sleep concerns are common in children with autism spectrum disorders (ASD). We identified objective sleep measures that differentiated ASD children with and without parental sleep concerns, and related parental concerns and objective measures to aspects of daytime behavior. ASD poor sleepers differed from ASD good sleepers on actigraphic (sleep latency, sleep efficiency, fragmentation) and polysomnographic (sleep latency) measures, and were reported to have more inattention, hyperactivity, and restricted/repetitive behaviors. Fragmentation was correlated with more restricted/repetitive behaviors. This work provides the foundation for focused studies of pathophysiology and targeted interventions to improve sleep in this population.
摘要
睡眠问题在自闭症谱系障碍（ASD）儿童中很常见。我们确定了客观的睡眠指标，这些指标能够区分有或没有父母睡眠担忧的ASD儿童，并将父母的担忧和客观指标与白天行为的各个方面联系起来。ASD睡眠不佳的儿童与睡眠良好的儿童在活动记录仪测量（睡眠潜伏期、睡眠效率、睡眠碎片化）和多导睡眠图测量（睡眠潜伏期）方面存在差异，并且据报道，他们有更多注意力不集中、多动以及受限/重复行为。睡眠碎片化与更多受限/重复行为相关。这项工作为针对该人群睡眠改善的病理生理学重点研究和靶向干预奠定了基础。
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