Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Diabetes Care. 2010 May;33(5):1140-2. doi: 10.2337/dc09-2124. Epub 2010 Feb 25.
The role of oxidative damage in the pathogenesis of metabolic syndrome is poorly understood.
A detailed cross-sectional study was performed to assess the relationship between lipid oxidation products, gamma-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect to the metabolic status in a cohort of otherwise healthy individuals.
A total of 179 individuals (87 men and 92 women) aged 43 +/- 14 years (mean +/- SD) participated in this study. There were no differences in the levels of plasma F(2)-isoprostanes, hydroxyeicosatetraenoic acids, cholesterol oxidation products, and phospholipase activities in individuals with features of metabolic syndrome. In multivariate analyses, serum hs-CRP was a consistent independent predictor of metabolic syndrome.
Minimal changes were observed in multiple markers of oxidative damage in a well-characterized cohort of individuals with features of metabolic syndrome.
氧化损伤在代谢综合征发病机制中的作用尚未明确。
我们进行了一项详细的横断面研究，以评估脂质氧化产物、γ-谷氨酰转肽酶、高敏 C 反应蛋白（hs-CRP）和磷脂酶活性与代谢状态之间的关系，该研究纳入了一组其他方面健康的个体。
共有 179 名年龄为 43 +/- 14 岁（均值 +/- 标准差）的个体（87 名男性和 92 名女性）参与了这项研究。在具有代谢综合征特征的个体中，血浆 F(2)-异前列腺素、羟二十碳四烯酸、胆固醇氧化产物和磷脂酶活性的水平没有差异。在多变量分析中，血清 hs-CRP 是代谢综合征的一个一致的独立预测因子。
在具有代谢综合征特征的特征明确的个体中，多种氧化损伤标志物的变化很小。
