在代谢综合征患者中，未发现其他健康个体的氧化损伤标志物升高。
Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome.
机构信息
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
出版信息
Diabetes Care. 2010 May;33(5):1140-2. doi: 10.2337/dc09-2124. Epub 2010 Feb 25.
Abstract
OBJECTIVE
The role of oxidative damage in the pathogenesis of metabolic syndrome is poorly understood.
RESEARCH DESIGN AND METHODS
A detailed cross-sectional study was performed to assess the relationship between lipid oxidation products, gamma-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect to the metabolic status in a cohort of otherwise healthy individuals.
RESULTS
A total of 179 individuals (87 men and 92 women) aged 43 +/- 14 years (mean +/- SD) participated in this study. There were no differences in the levels of plasma F(2)-isoprostanes, hydroxyeicosatetraenoic acids, cholesterol oxidation products, and phospholipase activities in individuals with features of metabolic syndrome. In multivariate analyses, serum hs-CRP was a consistent independent predictor of metabolic syndrome.
CONCLUSIONS
Minimal changes were observed in multiple markers of oxidative damage in a well-characterized cohort of individuals with features of metabolic syndrome.
摘要
目的
氧化损伤在代谢综合征发病机制中的作用尚未明确。
研究设计和方法
我们进行了一项详细的横断面研究，以评估脂质氧化产物、γ-谷氨酰转肽酶、高敏 C 反应蛋白（hs-CRP）和磷脂酶活性与代谢状态之间的关系，该研究纳入了一组其他方面健康的个体。
结果
共有 179 名年龄为 43 +/- 14 岁（均值 +/- 标准差）的个体（87 名男性和 92 名女性）参与了这项研究。在具有代谢综合征特征的个体中，血浆 F(2)-异前列腺素、羟二十碳四烯酸、胆固醇氧化产物和磷脂酶活性的水平没有差异。在多变量分析中，血清 hs-CRP 是代谢综合征的一个一致的独立预测因子。
结论
在具有代谢综合征特征的特征明确的个体中，多种氧化损伤标志物的变化很小。
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