Naunheim K S, Kesler K A, Fiore A C, Turrentine M, Hammell L M, Brown J W, Mohammed Y, Pennington D G
Department of Cardiothoracic Surgery, St. Louis University Medical Center, MO.
Eur J Cardiothorac Surg. 1991;5(2):99-103; discussion 104. doi: 10.1016/1010-7940(91)90007-7.
The optimal management of effusive pericardial disease remains controversial. Subxiphoid drainage has been criticized for a high recurrence rate while transthoracic procedures (window or pericardiectomy) are more invasive operations with greater potential for morbidity. We compared subxiphoid (SX group) and transthoracic (TT group) drainage in 131 patients (age range from 1 month to 81 years) treated from 1979 to the present. The etiology of effusion included cancer (38), uremia (24), infection (27), radiation (9), and other (33) causes. The two groups had similar age and sex distribution, etiology, and fluid volume. There was no difference in the operative mortality between the two groups (SX 15%, TT 13%, p = NS). Patients undergoing thoracotomy for treatment of effusive pericardial disease had a higher incidence of respiratory complications as defined by the presence of pneumonia, pleural effusion, prolonged ventilation, and need for reintubation (SX 11%, TT 35%, p less than 0.005). This may account, in part, for the longer mean hospital stay in transthoracic group (14.4 vs. 11.4 days). Nine patients were lost to follow-up after hospital discharge. The remaining 104 hospital survivors were followed for between 1 month and 11 years (mean 34 months, cumulative of 297 patient years). Three patients in each group experienced fluid recurrence and all but one were successfully treated by needle aspiration or percutaneous catheter placement. Following discharge, no patient required reoperation for effusive or constrictive pericardial disease or died from tamponade. There were no significant differences in 5-year actuarial survival (SX 54%, TT 49%) or actuarial freedom from recurrence (SX 89%, TT 93%).(ABSTRACT TRUNCATED AT 250 WORDS)
渗出性心包疾病的最佳治疗方法仍存在争议。剑突下引流因复发率高而受到批评,而开胸手术(开窗或心包切除术)则是侵入性更强的手术,发病风险更大。我们比较了1979年至今接受治疗的131例患者(年龄范围从1个月至81岁)的剑突下引流(SX组)和开胸引流(TT组)情况。积液的病因包括癌症(38例)、尿毒症(24例)、感染(27例)、放疗(9例)和其他(33例)病因。两组在年龄、性别分布、病因和积液量方面相似。两组手术死亡率无差异(SX组15%,TT组13%,p = 无显著性差异)。接受开胸手术治疗渗出性心包疾病的患者,肺炎、胸腔积液、通气延长以及需要再次插管等所定义的呼吸并发症发生率更高(SX组11%,TT组35%,p < 0.005)。这可能部分解释了开胸组平均住院时间更长(14.4天对11.4天)的原因。9例患者出院后失访。其余104例住院幸存者随访了1个月至11年(平均34个月,累计297患者年)。每组有3例患者出现积液复发,除1例患者外,其余均通过穿刺抽吸或经皮导管置入成功治疗。出院后,没有患者因渗出性或缩窄性心包疾病需要再次手术或死于心脏压塞。5年精算生存率(SX组54%,TT组49%)或无复发精算生存率(SX组89%,TT组93%)无显著差异。(摘要截短于250字)