铑催化的 2-苯基吲哚与炔烃的氧化偶联/环化反应：通过 C-H 和 N-H 键的断裂，以空气为氧化剂。
Rhodium-catalyzed oxidative coupling/cyclization of 2-phenylindoles with alkynes via C-H and N-H bond cleavages with air as the oxidant.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2010 May 7;12(9):2068-71. doi: 10.1021/ol100560k.
PMID:20377234
Abstract
The straightforward and efficient synthesis of indolo[2,1-a]isoquinoline derivatives has been achieved by the rhodium-catalyzed aerobic oxidative coupling/cyclization of 2-phenylindoles with alkynes. Some of the polycyclic products exhibit solid-state fluorescence.
摘要
通过铑催化的有氧氧化偶联/环化反应，实现了 2-苯基吲哚与炔烃的直接高效合成吲哚并[2,1-a]异喹啉衍生物。一些多环产物具有固态荧光。
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