Department of Radiology, University of Washington, Seattle, Washington 98195, USA.
Magn Reson Med. 2010 Mar;63(3):570-3. doi: 10.1002/mrm.22298.
This report describes recent efforts on our continuous development of a synthetic signal injection method for quantification of metabolite content in MR spectroscopy and MRI. Previous work showed that conversion of spectral peaks to quantitative units of metabolite content could be achieved with a calibrated synthetic free induction decay generated by an inductively coupled injection coil. This work demonstrates that calibrated synthetic voxels, injected in the same manner, can be used to quantify metabolite content in real (19)F image voxels. Images of vials containing different concentrations of sodium fluoride (NaF) were converted to units of moles by reference to precalibrated synthetically injected voxels. Additional images of vials containing variable sodium chloride (NaCl) demonstrate that the quantification process is robust and immune to changes in coil loading conditions.
本报告描述了我们在合成信号注入方法方面的最新进展，该方法可用于定量磁共振波谱和磁共振成像中的代谢物含量。先前的工作表明，通过感应耦合注入线圈产生的校准后的合成自由感应衰减，可以将光谱峰转换为代谢物含量的定量单位。这项工作表明，以相同的方式注入校准后的合成体素，可以用于定量真实（19）F 图像体素中的代谢物含量。通过参考预先校准的合成注入体素来将含有不同浓度氟化钠（NaF）的小瓶的图像转换为摩尔单位。含有可变氯化钠（NaCl）的小瓶的其他图像表明，定量过程是稳健的，并且不受线圈加载条件变化的影响。
