Sarkar Rashmi, Bansal Shuchi, Garg Vijay K
Department of Dermatology, Maulana Azad Medical College, and Lok Nayak Hospital, New Delhi, India.
J Cutan Aesthet Surg. 2012 Oct;5(4):247-53. doi: 10.4103/0974-2077.104912.
Melasma is a common disorder of hyperpigmentation, which has a severe impact on the quality of life. Inspite of tremendous research, the treatment remains frustrating both to the patient and the treating physician. Dark skin types (Fitzpatrick types IV to VI) are especially difficult to treat owing to the increased risk of post-inflammatory hyperpigmentation (PIH). The treatment ranges from a variety of easily applied topical therapies to agents like lasers and chemical peels. Peels are a well-known modality of treatment for melasma, having shown promising results in many clinical trials. However, in darker races, the choice of the peeling agent becomes relatively limited; so, there is the need for priming agents and additional maintenance peels. Although a number of new agents have come up, there is little published evidence supporting their use in day-to -day practice. The traditional glycolic peels prove to be the best both in terms of safety as well as efficacy. Lactic acid peels being relatively inexpensive and having shown equally good results in a few studies, definitely need further experimentation. We also recommend the use of a new peeling agent, the easy phytic solution, which does not require neutralisation unlike the traditional alpha-hydroxy peels. The choice of peeling agent, the peel concentration as well as the frequency and duration of peels are all important to achieve optimum results.
黄褐斑是一种常见的色素沉着紊乱疾病,对生活质量有严重影响。尽管进行了大量研究,但治疗对患者和治疗医生来说仍然令人沮丧。深色皮肤类型(菲茨帕特里克IV型至VI型)由于炎症后色素沉着(PIH)风险增加,尤其难以治疗。治疗方法从各种易于应用的局部疗法到激光和化学换肤等手段。换肤是一种众所周知的黄褐斑治疗方式,在许多临床试验中都显示出了有前景的结果。然而,在肤色较深的种族中,换肤剂的选择相对有限;因此,需要使用启动剂和额外的维持性换肤。尽管出现了许多新的药物,但几乎没有公开的证据支持它们在日常实践中的使用。传统的乙醇酸换肤在安全性和有效性方面都被证明是最好的。乳酸换肤相对便宜,并且在一些研究中也显示出了同样好的效果,肯定需要进一步试验。我们还推荐使用一种新的换肤剂——简易植酸溶液,与传统的α-羟基换肤不同,它不需要中和。为了达到最佳效果,换肤剂的选择、换肤浓度以及换肤的频率和持续时间都很重要。