Cheng Shi-Yie, Lin En-Hung, Huang Jing-Shi, Wen Zhi-Hong, Duh Chang-Yih
Department of Marine Biotechnology and Resources, National Sun Yat-sen University.
Chem Pharm Bull (Tokyo). 2010 Mar;58(3):381-5. doi: 10.1248/cpb.58.381.
Chemical investigations of the Formosan soft coral Lemnalia flava have obtained a new ylangene-type sesquiterpenoid, (1S,2S,4R,6S,7R,8S)-4alpha-formyloxy-beta-ylangene (1), along with two known sesquiterpenoids, lemnalol (2) and isolemnalol (3). Three new nardosinane-type sesquiterpenoids, designated as paralemnolins J-L (4-6), and five known sesquiterpenoids (7-11), were isolated from the other soft coral Paralemnalia thyrsoides. The structures of metabolites 1 and 4-6 were elucidated through extensive spectroscopic analysis and chemical methods. Moreover, the anti-inflammatory activity of metabolites 1-7 and 11 was evaluated in vitro.
对台湾软珊瑚黄肉软柳珊瑚（Lemnalia flava）的化学研究得到了一种新的依兰烯型倍半萜，(1S,2S,4R,6S,7R,8S)-4α-甲酰氧基-β-依兰烯（1），以及两种已知的倍半萜，黄肉软柳珊瑚醇（2）和异黄肉软柳珊瑚醇（3）。从另一种软珊瑚聚伞软柳珊瑚（Paralemnalia thyrsoides）中分离出三种新的nardosinane型倍半萜，命名为聚伞软柳珊瑚素J-L（4-6），以及五种已知的倍半萜（7-11）。通过广泛的光谱分析和化学方法阐明了代谢产物1和4-6的结构。此外，还对代谢产物1-7和11的抗炎活性进行了体外评估。
