Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
Mar Drugs. 2011;9(9):1543-1553. doi: 10.3390/md9091543. Epub 2011 Sep 16.
Five new nardosinane-type sesquiterpenoids, paralemnolins Q-U (1-5), along with three known compounds (6-8), were isolated from the Formosan soft coral Paralemnalia thyrsoides. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods, and the absolute configuration of 1 was determined by the application of Mosher's method on 1. Among these metabolites, 1 and 3 are rarely found nardosinane-type sesquiterpenoids, possessing novel polycyclic structures. Compounds 1, 3, 6 and 7 were found to possess neuroprotective activity.
从台湾软珊瑚 Paralemnalia thyrsoides 中分离得到了五个新的纳迪烷型倍半萜类化合物，即 paralemnolins Q-U（1-5），以及三个已知化合物（6-8）。根据广泛的光谱方法阐明了新代谢产物的结构，并通过在 1 上应用 Mosher 法确定了 1 的绝对构型。在这些代谢产物中，1 和 3 是罕见的纳迪烷型倍半萜类化合物，具有新颖的多环结构。化合物 1、3、6 和 7 被发现具有神经保护活性。
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