Turtzo L Christine, McCullough Louise D
Departments of Neurology and Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, MC 1840, Farmington, CT 06030, USA, Tel.: +1 860 679 8939, ,
Future Neurol. 2010 Jan 1;5(1):47-59. doi: 10.2217/fnl.09.66.
Stroke is a sexually dimorphic disease, with differences between males and females observed both clinically and in the laboratory. While males have a higher incidence of stroke throughout much of the lifespan, aged females have a higher burden of stroke. Sex differences in stroke result from a combination of factors, including elements intrinsic to the sex chromosomes as well as the effects of sex hormone exposure throughout the lifespan. Research investigating the sexual dimorphism of stroke is only in the beginning stages, but early findings suggest that different cell death pathways are activated in males and females after ischemic stroke. A greater understanding of the mechanisms underlying sex differences in stroke will lead to more appropriate treatment strategies for patients of both sexes.
中风是一种具有性别差异的疾病，在临床和实验室研究中均观察到男性和女性之间存在差异。虽然在大部分生命阶段男性中风的发病率较高，但老年女性中风的负担更重。中风的性别差异是由多种因素共同导致的，包括性染色体的内在因素以及一生中接触性激素的影响。对中风性别差异的研究尚处于起步阶段，但早期研究结果表明，缺血性中风后男性和女性激活了不同的细胞死亡途径。更深入地了解中风性别差异背后的机制将有助于为男女患者制定更合适的治疗策略。
