Ji Shun-rong, Liu Chen, Zhang Bo, Yang Feng, Xu Jin, Long Jiang, Jin Chen, Fu De-liang, Ni Quan-xing, Yu Xian-jun
Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Biochim Biophys Acta. 2010 Aug;1806(1):29-35. doi: 10.1016/j.bbcan.2010.02.004. Epub 2010 Feb 26.
During the past years, great progress has been made in the field of nanomaterials given their great potential in biomedical applications. Carbon nanotubes (CNTs), due to their unique physicochemical properties, have become a popular tool in cancer diagnosis and therapy. They are considered one of the most promising nanomaterials with the capability of both detecting the cancerous cells and delivering drugs or small therapeutic molecules to these cells. Over the last several years, CNTs have been explored in almost every single cancer treatment modality, including drug delivery, lymphatic targeted chemotherapy, thermal therapy, photodynamic therapy, and gene therapy. In this review, we will show how they have been introduced into the diagnosis and treatment of cancer. Novel SWNT-based tumor-targeted drug delivery systems (DDS) will be highlighted. Furthermore, the in vitro and in vivo toxicity of CNTs reported in recent years will be summarized.
在过去几年中，鉴于纳米材料在生物医学应用中的巨大潜力，该领域取得了巨大进展。碳纳米管（CNTs）由于其独特的物理化学性质，已成为癌症诊断和治疗中的一种常用工具。它们被认为是最有前途的纳米材料之一，具有检测癌细胞以及向这些细胞递送药物或小分子治疗剂的能力。在过去几年中，几乎在每一种癌症治疗方式中都对碳纳米管进行了探索，包括药物递送、淋巴靶向化疗、热疗、光动力疗法和基因疗法。在本综述中，我们将展示它们是如何被引入癌症诊断和治疗的。将重点介绍基于新型单壁碳纳米管的肿瘤靶向药物递送系统（DDS）。此外，还将总结近年来报道的碳纳米管的体外和体内毒性。
