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医学中微纳机器人的进展:设计、驱动与变革性应用

Advancements in Micro/Nanorobots in Medicine: Design, Actuation, and Transformative Application.

作者信息

Weerarathna Induni Nayodhara, Kumar Praveen, Dzoagbe Hellen Yayra, Kiwanuka Lydia

机构信息

Department of Biomedical Sciences, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra-442001, India.

Department of Computer Science and Medical Engineering, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra-442001, India.

出版信息

ACS Omega. 2025 Feb 4;10(6):5214-5250. doi: 10.1021/acsomega.4c09806. eCollection 2025 Feb 18.

Abstract

In light of the ongoing technological transformation, embracing advancements that foster shared benefits is essential. Nanorobots, a breakthrough within nanotechnology, have demonstrated significant potential in fields such as medicine, where diagnostic and therapeutic applications are the primary focus areas. This review provides a comprehensive overview of nanotechnology, robots, and their evolving role in medical applications, particularly highlighting the use of nanorobots. Various design strategies and operational principles, including sensors, actuators, and nanocontrollers, are discussed based on prior research. Key nanorobot medical applications include biomedical imaging, biosensing, minimally invasive surgery, and targeted drug delivery, each utilizing advanced actuation technologies to enhance precision. The paper further examines recent progress in micro/nanorobot actuation and addresses important considerations for the future, including biocompatibility, control, navigation, delivery, targeting, safety, and ethical implications. This review offers a holistic perspective on how nanorobots can reshape medical practices, paving the way for precision medicine and improved patient outcomes.

摘要

鉴于当前的技术变革,拥抱能带来共同利益的进步至关重要。纳米机器人是纳米技术领域的一项突破,已在医学等领域展现出巨大潜力,诊断和治疗应用是其主要关注领域。本综述全面概述了纳米技术、机器人及其在医学应用中不断演变的作用,尤其突出了纳米机器人的应用。基于先前的研究,讨论了各种设计策略和操作原理,包括传感器、致动器和纳米控制器。纳米机器人的关键医学应用包括生物医学成像、生物传感、微创手术和靶向给药,每项应用都利用先进的驱动技术来提高精度。本文进一步研究了微/纳米机器人驱动的最新进展,并探讨了未来的重要考量因素,包括生物相容性、控制、导航、递送、靶向、安全性和伦理影响。本综述全面阐述了纳米机器人如何重塑医疗实践,为精准医学和改善患者预后铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/812d/11840590/6059377842e4/ao4c09806_0001.jpg

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