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Systematic variation improves reproducibility of animal experiments.

作者信息

Richter S Helene, Garner Joseph P, Auer Corinna, Kunert Joachim, Würbel Hanno

机构信息

Behavioural Biology, University of Münster, Münster, Germany.

出版信息

Nat Methods. 2010 Mar;7(3):167-8. doi: 10.1038/nmeth0310-167.

DOI:10.1038/nmeth0310-167
PMID:20195246
Abstract
摘要

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Environmental standardization: cure or cause of poor reproducibility in animal experiments?环境标准化：动物实验中重现性差的解决之道还是成因？
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Questioning standardization in science.质疑科学中的标准化。
Nat Methods. 2009 Apr;6(4):253-4. doi: 10.1038/nmeth0409-253.
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Independence and reproducibility across microarray platforms.跨微阵列平台的独立性和可重复性。
卵石到金属：一种用于培养斑马鱼的富集方法。
PLoS One. 2024 May 7;19(5):e0298657. doi: 10.1371/journal.pone.0298657. eCollection 2024.
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Understanding Individual Subject Differences through Large Behavioral Datasets: Analytical and Statistical Considerations.通过大型行为数据集理解个体差异：分析与统计考量
Perspect Behav Sci. 2023 Sep 11;47(1):225-250. doi: 10.1007/s40614-023-00388-9. eCollection 2024 Mar.
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The Effect of Micronutrients on Obese Phenotype of Adult Mice Is Dependent on the Experimental Environment.微量营养素对成年肥胖小鼠表型的影响取决于实验环境。
Nutrients. 2024 Feb 29;16(5):696. doi: 10.3390/nu16050696.
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Behavioral Interventions Can Improve Brain Injury-Induced Deficits in Behavioral Flexibility and Impulsivity Linked to Impaired Reward-Feedback Beta Oscillations.行为干预可以改善脑损伤引起的行为灵活性和冲动性缺陷，这些缺陷与受损的奖励反馈β振荡有关。
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A Review of the Effects of Some Extrinsic Factors on Mice Used in Research.某些外在因素对用于研究的小鼠的影响综述
Comp Med. 2023 Dec 1;73(6):413-431. doi: 10.30802/AALAS-CM-23-000028.
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Finding the right power balance: Better study design and collaboration can reduce dependence on statistical power.找到合适的权力平衡：更好的研究设计和协作可以减少对统计功效的依赖。
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Lab Anim (NY). 2024 Jan;53(1):18-22. doi: 10.1038/s41684-023-01307-w. Epub 2023 Dec 27.
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Narrowing the translational research gap by aligning replication concepts in basic and clinical neuroscience.通过在基础和临床神经科学中调整复制概念来缩小转化研究差距。
J Neurosci Methods. 2023 May 15;392:109878. doi: 10.1016/j.jneumeth.2023.109878. Epub 2023 May 9.
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Behaviour and the standardization fallacy.行为与标准化谬误。
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