牙龈卟啉单胞菌的 rag 基因座可能来源于拟杆菌属，通过水平基因转移。
The rag locus of Porphyromonas gingivalis might arise from Bacteroides via horizontal gene transfer.
机构信息
Department of Immunology and Laboratory Immunology, Center of Medical Laboratory, Jiangsu University, Zhenjiang, China.
出版信息
Eur J Clin Microbiol Infect Dis. 2010 Apr;29(4):429-37. doi: 10.1007/s10096-010-0880-8. Epub 2010 Mar 2.
Porphyromonas gingivalis is regarded as one of the risk factors of periodontitis. P. gingivalis exhibits a wide variety of genotypes. Many insertion sequences (ISs), located in their chromosomes, made P. gingivalis differentiate into virulent and avirulent strains. In this research, we investigated the prevalence of P. gingivalis in the gingival crevicular fluid (GCF) among periodontitis patients from Zhenjiang, China, detected the P. gingivalis rag locus distributions by multiplex polymerase chain reaction (PCR), and analyzed the origin of the P. gingivalis rag locus based on evolution. There were three rag locus variants co-existing in Zhenjiang. The results showed that the rag locus may be associated with severe periodontitis. This work also firstly ascertained that the rag locus might arise, in theory, from Bacteroides sp. via horizontal gene transfer.
牙龈卟啉单胞菌被认为是牙周炎的危险因素之一。牙龈卟啉单胞菌表现出多种基因型。许多插入序列（IS）位于其染色体中，使牙龈卟啉单胞菌分化为毒力和非毒力菌株。在这项研究中，我们调查了中国镇江牙周炎患者龈沟液（GCF）中牙龈卟啉单胞菌的流行情况，通过多重聚合酶链反应（PCR）检测了牙龈卟啉单胞菌 rag 基因座的分布，并基于进化分析了牙龈卟啉单胞菌 rag 基因座的起源。在镇江存在三种共存的 rag 基因座变体。结果表明，rag 基因座可能与严重的牙周炎有关。这项工作还首次确定，从理论上讲，rag 基因座可能通过水平基因转移来自拟杆菌属。
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