Bodsworth N J, Cooper D A, Donovan B
Department of Public Health, University of Sydney, Australia.
J Infect Dis. 1991 May;163(5):1138-40. doi: 10.1093/infdis/163.5.1138.
To assess the influence of human immunodeficiency virus type 1 (HIV-1) infection on the natural history of acute hepatitis B virus (HBV) infection, a study was undertaken of the clinical records of all 77 homosexual men with documented seroconversion to anti-hepatitis B core antibody (anti-HBc) between visits to either of two Sydney clinics between 1985 and 1989. HIV-1-seropositive subjects developed chronic HBV infection (positive for hepatitis B surface antigen [HBsAg] greater than 6 months) more frequently (7/31, 23%) than HIV-1-seronegative ones (2/46, 4%; P = .026). HIV-positive subjects who cleared HBsAg had significantly more circulating CD4+ lymphocytes (mean, 547 x 10(6)/l) than those who did not (352 x 10(6)/l, P less than .005). A subset of subjects who acquired both viruses between visits had an even higher rate of chronic infection (4/10, 40%). Icteric illnesses were reported more frequently by HIV-1-seronegative (11/46, 24%) than -seropositive subjects (3/31, 10%; P = .20). These findings indicate a potential for an increased reservoir of HBV infection in the community as a consequence of the HIV-1 epidemic.
为评估1型人类免疫缺陷病毒（HIV-1）感染对急性乙型肝炎病毒（HBV）感染自然史的影响，对1985年至1989年间在悉尼两家诊所就诊期间记录血清转化为抗乙型肝炎核心抗体（抗-HBc）的所有77名同性恋男性的临床记录进行了研究。HIV-1血清阳性受试者比HIV-1血清阴性受试者更频繁地发生慢性HBV感染（乙型肝炎表面抗原[HBsAg]阳性超过6个月）（7/31，23%对比2/46，4%；P = .026）。清除HBsAg的HIV阳性受试者的循环CD4+淋巴细胞明显多于未清除者（平均547×10⁶/l对比352×10⁶/l，P小于.005）。在两次就诊期间同时感染两种病毒的受试者亚组慢性感染率更高（4/10，40%）。HIV-1血清阴性受试者（11/46，24%）比血清阳性受试者（3/31，10%；P = .20）更频繁地报告黄疸性疾病。这些发现表明，由于HIV-1流行，社区中HBV感染的潜在储存库可能增加。
