Department of Endocrinology, Christie Hospital, Manchester, UK.
Horm Res Paediatr. 2010;73(3):153-60. doi: 10.1159/000284355. Epub 2010 Mar 3.
Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects.
在肥胖症患者中，儿童和成人的生长激素（GH）分泌会受到深度抑制，但这种抑制是可逆的。由于 GH 缺乏会导致脂肪量增加，因此区分这两种情况具有一定的挑战性。本文综述了肥胖症对 GH 分泌产生抑制作用的已知和推测机制，包括 IGF-I 和胰岛素等外周因素，以及下丘脑/垂体的中枢调节剂。我们还讨论了目前在肥胖症患者中检测 GH 缺乏的依据，以及超重受试者中各种激发试验的有效性。
