Leviel V, Beillevaire T, Naquet R
Rev Electroencephalogr Neurophysiol Clin. 1977 Apr-Jun;7(2):225-31. doi: 10.1016/s0370-4475(77)80090-7.
Methyl-2 (2 Naphtyl) Aziridine (MNA) is a new agent which has been demonstrated to have effects on paradoxical sleep (PS) and on the levels of cerebral noradrenaline (Yamamoto, 1975). It has been tried on a experimental model of epilepsy, the kindling effect, produced in the cat by repetitive stimulation of the amygdala. The results obtained in the cat confirmed blockage of paradoxical sleep (PS) and revealed a marked reduction in the number of stimuli required to produce the effect. The shortening of the time before the first generalised seizure did not seem attributable to privation of paradoxical sleep. The role of cerebral catecholamine reduction, however, is discussed.
甲基 -2（2 - 萘基）氮丙啶（MNA）是一种新型药物，已被证明对异相睡眠（PS）和脑去甲肾上腺素水平有影响（山本，1975年）。它已在癫痫实验模型——通过反复刺激猫的杏仁核产生的点燃效应上进行了试验。在猫身上获得的结果证实了异相睡眠（PS）被阻断，并显示产生该效应所需的刺激次数显著减少。首次全身性发作前时间的缩短似乎并非归因于异相睡眠的剥夺。然而，文中讨论了脑儿茶酚胺减少的作用。
