Department of Neurology, College of Medicine, Myongji Hospital, Kwandong University, Gyeonggi-do, Korea.
Neurol Sci. 2010 Dec;31(6):785-8. doi: 10.1007/s10072-010-0236-2. Epub 2010 Mar 3.
Vogt-Koyanagi-Harada (VKH) disease is a systemic disease consisting of bilateral granulomatous panuveitis combined with cutaneous and neurologic manifestations. However, there have been few reports of brain magnetic resonance imaging (MRI) in VKH disease. A 54-year-old Korean woman presented with severe periorbital pain, blurred vision and meningismus. Ophthalmologic examination disclosed bilateral optic disc edema with peripapillary nerve fiber hemorrhages. Lumbar puncture revealed monocytic pleocytosis. After a diagnosis of VKH disease was made, the patient was treated with high-dose corticosteroid. Brain MRI showed diffusely thickened posterior ocular walls with retinal detachment and perineural infiltrative changes along the optic nerves and adjacent pachymeningeal enhancement of the anterior temporal lobes bilaterally. We report a case of VKH disease with panuveitis and meningeal involvement of the anterior temporal lobe detected by brain MRI.
Vogt-Koyanagi-Harada（VKH）病是一种全身性疾病，由双侧肉芽肿性全葡萄膜炎合并皮肤和神经系统表现组成。然而，关于 VKH 病的脑部磁共振成像（MRI）报道很少。一名 54 岁韩国女性因严重眼眶疼痛、视力模糊和脑膜刺激征就诊。眼科检查显示双侧视盘水肿伴视盘周围神经纤维出血。腰椎穿刺显示单核细胞增多症。在诊断为 VKH 病后，患者接受了大剂量皮质类固醇治疗。脑部 MRI 显示双侧后眼球壁弥漫性增厚，伴有视网膜脱离，视神经和邻近硬脑膜沿视神经和邻近硬脑膜双侧前颞叶浸润性改变。我们报告一例 VKH 病伴全葡萄膜炎和脑膜受累的前颞叶，通过脑部 MRI 检测到。
