Eichenfield Lawrence F, McCollum Alexandra, Msika Philippe
Pediatrics and Medicine (Dermatology), Pediatric and Adolescent Dermatology, Rady Children's Hospital, University of California San Diego School of Medicine, San Diego, California 92130, USA.
Pediatr Dermatol. 2009 Nov-Dec;26(6):669-75. doi: 10.1111/j.1525-1470.2009.01042.x.
For millennia, sunflower seed oil has been used in folk medicine for both skin care and the treatment of skin disorders. In its natural state, the oil contains high levels of essential fatty acids, particularly linoleic acid, which has skin barrier-enhancing properties. A sunflower oleodistillate (SOD), which is produced through a molecular distillation process without the use of solvents, has been shown to increase the epidermal key lipid synthesis and to reduce inflammation in vitro and in animal models. It has also been shown to activate peroxisome proliferative-activated receptor-alpha (PPAR-alpha) in vitro. As PPAR-alpha agonists have been shown to stimulate keratinocyte differentiation, improve barrier function, and enhance lipid metabolism in the skin, it has been suggested that SOD might also be efficacious in atopic dermatitis (AD). An initial clinical evaluation of the care effect of a 2% SOD emulsion in 20 adult volunteers with atopic skin revealed the moisturizing properties of SOD. Finally, a strong steroid-sparing effect and a positive effect on quality-of-life parameters were clearly demonstrated for the 2% SOD cream in studies in infants and babies with AD.
数千年来，葵花籽油一直被用于民间医学，用于皮肤护理和治疗皮肤疾病。在其自然状态下，这种油含有高水平的必需脂肪酸，尤其是亚油酸，它具有增强皮肤屏障的特性。一种通过分子蒸馏工艺生产且不使用溶剂的葵花籽油脂馏出物（SOD），已被证明在体外和动物模型中可增加表皮关键脂质合成并减轻炎症。它在体外还被证明可激活过氧化物酶体增殖物激活受体α（PPAR-α）。由于PPAR-α激动剂已被证明可刺激角质形成细胞分化、改善屏障功能并增强皮肤脂质代谢，因此有人提出SOD可能对特应性皮炎（AD）也有效。对20名患有特应性皮肤的成年志愿者使用2% SOD乳液的护理效果进行的初步临床评估揭示了SOD的保湿特性。最后，在针对患有AD的婴幼儿的研究中，2% SOD乳膏的强大的激素节省效应和对生活质量参数的积极作用得到了明确证明。
