Department of Psychiatry, University of Melbourne, Australia.
Acta Psychiatr Scand. 2010 May;121(5):377-84. doi: 10.1111/j.1600-0447.2010.01542.x. Epub 2010 Feb 25.
We aimed to replicate a recent finding of high prevalence of trauma history in patients at 'ultra-high risk' (UHR) of psychotic disorder and to investigate whether trauma predicts conversion to psychosis in this population.
A consecutive sample of UHR patients was assessed. History of trauma was accessed with the General Trauma Questionnaire. Cox regression models were used to explore relationship between conversion to psychosis and trauma.
Of 92 UHR patients nearly 70% had experienced a traumatic event and 21.7% developed psychosis during follow-up (mean 615 days). Patients who had experienced a sexual trauma (36%) were significantly more likely to convert to first-episode psychosis (OR 2.96) after controlling for meeting multiple UHR intake groups.
UHR patients have a high prevalence of history of trauma. Previous sexual trauma may be a predictor of onset of psychotic disorder in this population.
我们旨在复制最近的一项发现，即在精神病超高风险（UHR）患者中，创伤史的发生率很高，并探讨创伤是否会预测该人群向精神病的转化。
对连续的 UHR 患者样本进行评估。使用一般创伤问卷来评估创伤史。使用 Cox 回归模型来探索向精神病转化与创伤之间的关系。
在 92 名 UHR 患者中，近 70%的患者经历过创伤事件，在随访期间（平均 615 天）有 21.7%的患者发展为精神病。在控制符合多个 UHR 纳入标准的情况下，经历过性创伤（36%）的患者更有可能发展为首发精神病（OR 2.96）。
UHR 患者有很高的创伤史发生率。既往性创伤可能是该人群精神病发病的预测因素。
