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alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding.经过改造成为非天然且无活性的α-乳白蛋白,在与油酸结合时会杀死肿瘤细胞:这是部分去折叠产生的一种新生物学功能。
J Mol Biol. 2009 Dec 18;394(5):994-1010. doi: 10.1016/j.jmb.2009.09.026. Epub 2009 Sep 18.
2
Modeling a congenital disorder of glycosylation type I in C. elegans: a genome-wide RNAi screen for N-glycosylation-dependent loci.在秀丽隐杆线虫中模拟 I 型糖基化先天性缺陷:一个用于 N-糖基化依赖基因座的全基因组 RNAi 筛选。
Glycobiology. 2009 Dec;19(12):1554-62. doi: 10.1093/glycob/cwp136. Epub 2009 Sep 3.
3
Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa.Fut2- 基因敲除小鼠表现出糖基化模式改变和 BabA 介导的幽门螺杆菌黏附胃黏膜能力受损。
Glycobiology. 2009 Dec;19(12):1525-36. doi: 10.1093/glycob/cwp131. Epub 2009 Aug 25.
4
Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice.通过半乳糖凝集素-9与T细胞免疫球蛋白粘蛋白3相互作用减弱Th1反应可抑制非肥胖糖尿病(NOD)小鼠的自身免疫性糖尿病。
Eur J Immunol. 2009 Sep;39(9):2403-11. doi: 10.1002/eji.200839177.
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Detection of differentially expressed wound-healing-related glycogenes in galectin-3-deficient mice.在半乳糖凝集素-3缺陷小鼠中检测差异表达的伤口愈合相关糖基因。
Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5690-6. doi: 10.1167/iovs.08-3359. Epub 2009 Jul 30.
6
Alteration of the glycosylation pattern of monocytic THP-1 cells upon differentiation and its impact on lectin-mediated drug delivery.单核细胞 THP-1 细胞分化时糖基化模式的改变及其对凝集素介导的药物传递的影响。
Eur J Pharm Biopharm. 2009 Nov;73(3):324-30. doi: 10.1016/j.ejpb.2009.07.004. Epub 2009 Jul 12.
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Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.半乳糖凝集素-1 通过 p44/42 MAP 激酶途径和百日咳毒素敏感途径刺激单核细胞趋化。
Glycobiology. 2009 Dec;19(12):1402-7. doi: 10.1093/glycob/cwp077. Epub 2009 Jun 26.
8
Recent advances in carbohydrate-based vaccines.基于碳水化合物的疫苗的最新进展。
Curr Opin Chem Biol. 2009 Jun;13(3):354-9. doi: 10.1016/j.cbpa.2009.05.127. Epub 2009 Jun 25.
9
Unusual accumulation of sulfated glycosphingolipids in colon cancer cells.硫酸化糖鞘脂在结肠癌细胞中的异常蓄积。
Glycobiology. 2009 Sep;19(9):1018-33. doi: 10.1093/glycob/cwp083. Epub 2009 Jun 18.
10
A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction.一种新产生的功能性抗体将Tn抗原鉴定为癌细胞与淋巴管内皮细胞相互作用中的一种新型决定因素。
Glycobiology. 2009 Oct;19(10):1056-67. doi: 10.1093/glycob/cwp085. Epub 2009 Jun 15.

糖生物学综述:碳水化合物、凝集素及其在癌症治疗中的意义。

A glycobiology review: carbohydrates, lectins and implications in cancer therapeutics.

机构信息

Department of Biology and Center for Cancer and Developmental Biology, California State University Northridge, 18111 Nordhoff Street, Northridge, CA 91330-8303, USA.

出版信息

Acta Histochem. 2011 May;113(3):236-47. doi: 10.1016/j.acthis.2010.02.004. Epub 2010 Mar 2.

DOI:10.1016/j.acthis.2010.02.004
PMID:20199800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3027850/
Abstract

This review is intended for general readers who would like a basic foundation in carbohydrate structure and function, lectin biology, and the implications of glycobiology in human health and disease, particularly in cancer therapeutics. These topics are among the hundreds included in the field of glycobiology and are treated here because they form the cornerstone of glycobiology or the focus of many advances in this rapidly expanding field.

摘要

这篇综述面向希望对碳水化合物结构和功能、凝集素生物学以及糖生物学在人类健康和疾病(特别是癌症治疗)中的意义有基本了解的一般读者。这些主题是糖生物学领域的数百个主题之一,之所以在这里讨论,是因为它们构成了糖生物学的基石,或者是这个快速发展领域中许多进展的重点。