宏量营养素摄入会引起氧化和炎症应激：与动脉粥样硬化和胰岛素抵抗的潜在相关性。
Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance.
机构信息
Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health 3 Gates Circle Buffalo, NY 14209, USA.
出版信息
Exp Mol Med. 2010 Apr 30;42(4):245-53. doi: 10.3858/emm.2010.42.4.033.
Abstract
With the global increase in the epidemic of obesity and type 2 diabetes with a concomitant increase in atherosclerotic disease, an investigation into the effects of various macronutrients and food products has become necessary. Such investigation will allow us to better understand the relationship between the intake of various macronutrients and the pathogenesis of mechanisms underlying the regulation of insulin sensitivity and resistance, oxidative stress and inflammation, the regulation of hunger and satiety and atherogenesis. This review covers the first decade of work in this area relating the intake of usual foods and diets to their immediate and long term outcomes. The review also covers the exciting novel area of anti-inflammatory effects of certain foods. Hopefully, a comprehensive understanding of these actions of macronutrients and their long term effects will allow us to formulate food combinations which will lead to healthy eating habits and improvement in our overall health status.
摘要
随着肥胖症和 2 型糖尿病在全球范围内的流行，以及动脉粥样硬化疾病的相应增加，对各种宏量营养素和食品的影响进行研究已变得必要。这种研究将使我们能够更好地理解各种宏量营养素的摄入与胰岛素敏感性和抵抗、氧化应激和炎症、饥饿和饱腹感以及动脉粥样硬化发生的调节机制之间的关系。本综述涵盖了该领域最初十年的工作，涉及到摄入常见食物和饮食与它们的即时和长期结果之间的关系。该综述还涵盖了某些食物具有抗炎作用这一令人兴奋的新领域。希望对这些宏量营养素的作用及其长期影响有一个全面的了解，将使我们能够制定出食物组合，从而导致健康的饮食习惯，并改善我们的整体健康状况。
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