Section of Oncology and Clinical Research, Leeds Institute of Molecular Medicine, Leeds, UK.
Eur J Immunol. 2010 Mar;40(3):631-4. doi: 10.1002/eji.200940162.
A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin-associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.
NLRP3 炎性小体在复发性和慢性炎症中的作用最初在一组罕见的自身炎症性疾病中被描述，这些疾病被称为冷吡啉相关周期性综合征。随后，炎性小体被认为与许多常见疾病的病理学有关，包括癌症、痛风和糖尿病。尽管存在多种病理学，但炎性小体在先天防御和肿瘤消除中的核心作用表明，在适当的情况下，有共同的治疗方法来减轻炎症。
