Centre for Contact Lens Research, School of Optometry, University of Waterloo, 200 University Ave. West, Waterloo, ON N2L3G1, Canada.
Cont Lens Anterior Eye. 2010 Aug;33(4):189-95. doi: 10.1016/j.clae.2010.01.006. Epub 2010 Mar 3.
To assess the clinical and subjective performance of a one-step hydrogen peroxide (H2O2) lens care system compared to a multi-purpose disinfecting system (MPDS) when used with silicone hydrogel (SiH) lenses.
This was an eight-week, contralateral (lens type) clinical trial with a randomized, cross-over (care system) design. The H2O2 system was Clear Care ((AO Sept Plus) CIBA VISION) and the MPDS was OPTI-FREE RepleniSH (Alcon) and the SiH materials were lotrafilcon B (Air Optix; CIBA VISION) and senofilcon A (Acuvue OASYS, Johnson & Johnson Vision Care). Investigators and subjects were masked to lens care and lens type, respectively. Clinical variables and ocular health assessments were conducted at a baseline, two-week and four-week visit for each cross-over phase. Comfort, dryness and vision were rated on 0-100 scales. Wearing times and comfortable wearing times were also recorded.
Twenty-six subjects were enrolled: nine male, 17 female, mean age (+/-standard deviation) 31+/-12 years (range 17-59 years) and 24 subjects completed the study. Clinical variables showed no difference between solutions (all p > 0.05), however one subject exhibited solution-induced corneal staining with both lens materials and the MPDS. There was no difference between solutions in subjective overall ratings of comfort, dryness or vision (p > 0.05). The H2O2 resulted in longer reported comfortable wearing times than the MPDS (10.93 +/- 1.71 vs 9.84 +/- 1.47 h; repeated measures ANOVA, p < 0.01).
While both lens care systems performed well with the SiH lenses used, the H2O2 resulted in a longer reported comfortable wearing time then the MPDS.
评估一步式过氧化氢（H2O2）镜片护理系统与多用途消毒系统（MPDS）在使用硅水凝胶（SiH）镜片时的临床和主观性能。
这是一项为期八周、双侧（镜片类型）的临床研究，采用随机、交叉（护理系统）设计。H2O2 系统为 Clear Care（（AO Sept Plus）CIBA VISION），MPDS 为 OPTI-FREE RepleniSH（Alcon），SiH 材料为 lotrafilcon B（Air Optix；CIBA VISION）和 senofilcon A（Acuvue OASYS，Johnson & Johnson Vision Care）。研究人员和受试者分别对镜片护理和镜片类型进行了掩蔽。在每个交叉阶段的基线、两周和四周就诊时，进行临床变量和眼部健康评估。舒适度、干燥度和视力均按 0-100 分进行评分。佩戴时间和舒适佩戴时间也被记录。
共有 26 名受试者入组：9 名男性，17 名女性，平均年龄（+/-标准差）31+/-12 岁（范围 17-59 岁），24 名受试者完成了研究。临床变量显示两种溶液之间无差异（均 p>0.05），但有一名受试者在两种镜片材料和 MPDS 下均出现溶液诱导的角膜染色。两种溶液在舒适度、干燥度或视力的主观整体评分方面无差异（p>0.05）。H2O2 比 MPDS 报告的舒适佩戴时间更长（10.93+/-1.71 对 9.84+/-1.47 h；重复测量方差分析，p<0.01）。
虽然两种镜片护理系统都能很好地用于 SiH 镜片，但 H2O2 比 MPDS 报告的舒适佩戴时间更长。
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