Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.
Adv Exp Med Biol. 2010;662:169-75. doi: 10.1007/978-1-4419-1241-1_24.
For resolving absolute concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy it is necessary to calculate the light scattering and absorption, at multiple wavelengths with some depth resolution. To achieve this we propose an instrumentation configuration that combines multi-distance frequency and broadband spectrometers to quantify chromophores in turbid media by using a hybrid spatially resolved algorithm. Preliminary results in solid phantoms as well as liquid dynamic homogeneous and inhomogeneous phantoms and in-vivo muscle measurements showed encouraging results.
为了利用近红外光谱法在人类成年大脑中确定组织色团的绝对浓度，需要以一定的深度分辨率，在多个波长下计算光散射和吸收。为了实现这一目标，我们提出了一种仪器配置，将多距离频率和宽带光谱仪相结合，通过使用混合空间分辨算法来量化混浊介质中的色团。在固体、液体动态均匀和不均匀的体模以及体内肌肉测量中的初步结果显示出了令人鼓舞的结果。
