Department of Medicine, Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Osteoarthritis Cartilage. 2010 Jun;18(6):825-9. doi: 10.1016/j.joca.2010.02.013. Epub 2010 Feb 17.
To test whether serum transforming growth factor-beta 1 (TGF-beta1) predicts incident and progressive hip or knee radiographic OA (rOA).
Serum TGF-beta1 was measured for 330 participants aged 45 years and older in the Johnston County Osteoarthritis Project, with paired longitudinal films available for 618 hips and 658 knees. Incident and progressive rOA were defined using Kellgren-Lawrence (K-L) grade as well as osteophyte (OST) and joint space narrowing (JSN) scores. Natural logarithm transformation was used to produce near-normal distributions for continuous TGF-beta1 (lnTGF-beta1). Separate multivariable Weibull regression models were used to provide hazard ratios (HRs) for a 1-unit increase lnTGF-beta1 with each rOA outcome, accounting for variable follow-up times and clustering by individual, adjusted for age, race, gender, and body mass index (BMI). Interaction terms were considered statistically significant at P<0.10.
The mean (+/-SD) age of the sample was 61.9+/-9.7 years, the mean BMI was 30.3+/-6.9 kg/m(2), with 60.6% women and 42.4% AA. The mean (+/-SD) TGF-beta1 was 17.8+/-6.1 ng/ml; follow-up time was 6.1+/-1.3 years. There were no significant interactions by race or gender. HRs showed no significant relationship between lnTGF-beta1 and incident or progressive rOA, OST, or JSN, at the knee or the hip.
Levels of TGF-beta1 do not predict incident or progressive rOA, OST, or JSN at the hip or knee in this longitudinal, population-based study, making it unlikely that TGF-beta1 will be a robust biomarker for rOA in future studies.
检验血清转化生长因子-β1（TGF-β1）是否能预测髋关节或膝关节的影像学骨关节炎（rOA）的发生和进展。
对约翰斯顿县骨关节炎项目中 330 名年龄在 45 岁及以上的参与者进行血清 TGF-β1 检测，618 个髋关节和 658 个膝关节均有配对的纵向 X 光片。通过 Kellgren-Lawrence（K-L）分级以及骨赘（OST）和关节间隙狭窄（JSN）评分来定义新发和进展性 rOA。对连续 TGF-β1（lnTGF-β1）进行自然对数转换，以产生接近正态分布。采用多变量 Weibull 回归模型，针对 rOA 每种结局，lnTGF-β1 每增加 1 单位，提供风险比（HR），同时考虑个体的可变随访时间和聚类，调整年龄、种族、性别和体重指数（BMI）。考虑到 P<0.10 的统计学意义，还考虑了交互项。
样本的平均（+/-SD）年龄为 61.9+/-9.7 岁，平均 BMI 为 30.3+/-6.9 kg/m2，女性占 60.6%，非裔美国人占 42.4%。平均（+/-SD）TGF-β1 为 17.8+/-6.1ng/ml；随访时间为 6.1+/-1.3 年。种族或性别没有显著的交互作用。HR 显示，lnTGF-β1 与膝关节或髋关节的新发或进展性 rOA、OST 或 JSN 之间无显著相关性。
在这项基于人群的纵向研究中，TGF-β1 水平与髋关节或膝关节的 rOA、OST 或 JSN 无显著相关性，这表明在未来的研究中，TGF-β1 不太可能成为 rOA 的一个稳健的生物标志物。
