持续性 HIV 的治疗。
Therapy for persistent HIV.
机构信息
Departments of Medicine, Chapel Hill, North Carolina 27599, USA.
出版信息
Trends Pharmacol Sci. 2010 May;31(5):206-11. doi: 10.1016/j.tips.2010.02.001. Epub 2010 Mar 5.
Abstract
Given the scope of the human immunodeficiency virus (HIV) pandemic, millions of people will need of chronic antiretroviral therapy (ART) for decades into the future. It is hoped that progress in prevention of HIV infection can be made, but there have been few successes in this effort thus far. ART also presents formidable problems. Therefore, research must continue on improvements in prevention and treatment, but future HIV research should now also seek to develop temporally contained therapies capable of eradicating HIV infection. This review will explore what is known about the mechanisms that restrain HIV expression and result in persistent, latent proviral infection, and what these mechanisms tell us about potential approaches towards eradication of HIV infection.
摘要
鉴于人类免疫缺陷病毒（HIV）大流行的范围，未来几十年，数百万人将需要长期接受抗逆转录病毒治疗（ART）。人们希望在预防 HIV 感染方面取得进展，但迄今为止，这方面的努力收效甚微。ART 也带来了巨大的问题。因此，必须继续研究预防和治疗方面的改进，但未来的 HIV 研究现在也应该寻求开发能够根除 HIV 感染的暂时有控制的治疗方法。这篇综述将探讨已知的限制 HIV 表达并导致持续潜伏性前病毒感染的机制，以及这些机制告诉我们在根除 HIV 感染方面的潜在方法。
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