HIV 组装和转运的新见解。
New insights into HIV assembly and trafficking.
机构信息
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA.
出版信息
Physiology (Bethesda). 2011 Aug;26(4):236-51. doi: 10.1152/physiol.00051.2010.
Abstract
Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag trafficking is currently one of the least understood aspects of HIV-1 replication. In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly.
摘要
人类免疫缺陷病毒 1（HIV-1）颗粒的组装和释放由病毒 Gag 多蛋白前体介导。Gag 在细胞质中合成，并迅速转运到膜上以协调颗粒的产生。HIV-1 Gag 运输的细胞生物学是 HIV-1 复制中了解最少的方面之一。在这篇综述中，我们强调了目前对参与 Gag 运输和病毒组装的细胞机制的理解。
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