Department of Laboratory Medicine, National Health Insurance Corporation, Ilsan Hospital, Goyang, Korea.
Am J Trop Med Hyg. 2010 Mar;82(3):412-4. doi: 10.4269/ajtmh.2010.09-0560.
Recently, the XE-2100 hematology analyzer was investigated in a rather small patient group; pseudoeosinophilia or abnormal white blood cell (WBC) scattergrams reported by this instrument were considered as significantly valuable diagnostic parameters in detecting vivax malaria. This study was conducted not only to assess the usefulness of pseudoeosinophilia or abnormal WBC scattergram in vivax malaria-endemic areas with large patient groups (N = 1,801) but also to investigate the correlation of parasitemia and platelet count with pseudoeosinophilia and abnormal WBC scattergrams. Of the 1,801 analyzed patients, 413 (22.9%) were found to have malaria by Wright-Giemsa stained blood smears. Overall, either pseudoeosinophilia or abnormal WBC scattergram was detected in 191 of 413 malaria patients and 4 of 1,388 patients without malaria (sensitivity = 46.2%, specificity = 99.7%). We suggest that clinical hematology laboratories using the XE-2100 analyzer should be aware of such specific parameters, even with the absence of a clinical request.
最近，XE-2100 血液分析仪在一个相当小的患者群体中进行了研究；该仪器报告的假性嗜酸性粒细胞增多或异常白细胞（WBC）散点图被认为是在检测间日疟原虫中具有重要价值的诊断参数。本研究不仅旨在评估在大患者群体（N=1801）的间日疟流行地区中假性嗜酸性粒细胞增多或异常 WBC 散点图的有用性，还旨在研究寄生虫血症和血小板计数与假性嗜酸性粒细胞增多和异常 WBC 散点图之间的相关性。在分析的 1801 例患者中，通过瑞氏染色血涂片发现 413 例（22.9%）患有疟疾。总体而言，在 413 例疟疾患者中有 191 例和 1388 例无疟疾患者中检测到假性嗜酸性粒细胞增多或异常 WBC 散点图（敏感性=46.2%，特异性=99.7%）。我们建议使用 XE-2100 分析仪的临床血液学实验室应注意这些特定参数，即使没有临床要求。
