Nyunaï Nyemb, Njikam Njifutié, Abdennebi El Hassane, Mbafor Joseph Tanyi, Lamnaouer Driss
Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Afr J Tradit Complement Altern Med. 2009 Mar 7;6(2):123-30.
The hypoglycaemic and antihyperglycaemic properties of the aqueous extracts of the leaves of Ageratum conyzoides L. were evaluated in normoglycemic and in streptozotocin-induced diabetic rats, in order to validate its use in folk medicine. Tested animals were given the aqueous extracts of the plant at the doses of 100, 200 and 300mg/kg. These doses were tested also on glucose loaded normal male rats (Oral Glucose Tolerance Test). Of all the doses, the aqueous extracts at 200 and 300mg/kg showed statistically significant hypoglycaemic and antihyperglycaemic activities. For the oral glucose tolerance test, 100mg/kg dose only attenuated significantly the rise of blood glucose in normal fasted rats. Consequently, these results confirmed the hypoglycaemic properties of the leaves of Ageratum conyzoides.
为验证藿香蓟叶水提取物在民间医学中的应用，对正常血糖和链脲佐菌素诱导的糖尿病大鼠的降血糖和抗高血糖特性进行了评估。给受试动物分别灌胃100、200和300mg/kg剂量的该植物水提取物。这些剂量也在葡萄糖负荷正常雄性大鼠上进行了测试（口服葡萄糖耐量试验）。在所有剂量中，200和300mg/kg的水提取物显示出具有统计学意义的降血糖和抗高血糖活性。对于口服葡萄糖耐量试验，仅100mg/kg剂量显著减弱了正常禁食大鼠的血糖升高。因此，这些结果证实了藿香蓟叶的降血糖特性。
