Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan.
Prev Med. 2010 May-Jun;50(5-6):272-6. doi: 10.1016/j.ypmed.2010.02.014. Epub 2010 Mar 4.
To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA+DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake.
We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA+DHA intake as the reference were calculated by logistic regression analysis.
Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9 years, 22.9 kg/m(2), and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25 kg/m(2) (P for interaction=0.033). However EPA+DHA showed no such associations consistently.
Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.
研究在 n-3 多不饱和脂肪酸（植物来源的α-亚麻酸：ALA，以及海洋来源的二十碳五烯酸和二十二碳六烯酸：EPA+DHA）摄入量较高的瘦人群体中，膳食 n-3 多不饱和脂肪酸摄入与胰岛素抵抗（IR）的相关性。
我们在 2002 年对 3383 名年龄在 35-66 岁的日本地方政府工作人员进行了横断面研究。IR 定义为稳态模型评估的最高四分位，营养素摄入量则由饮食史问卷估算。通过逻辑回归分析计算 ALA 或 EPA+DHA 摄入量最低四分位数为参考时，IR 的比值比（OR）。
平均年龄、体重指数（BMI）和膳食 ALA 以及膳食 EPA+DHA 的中位数分别为 47.9 岁、22.9kg/m(2)、1.90g/天（0.88%E）和 0.77g/天（0.36%E）。ALA 摄入量四分位数越高，IR 的 OR 越低（多变量调整后的 Q4 与 Q1 的 OR=0.74，P 趋势=0.01），且这种相关性仅在 BMI<25kg/m(2)的受试者中存在（交互作用 P=0.033）。然而，EPA+DHA 并未显示出一致的相关性。
在日本中年男女正常体重人群中，较高的 ALA 摄入与较低的 IR 患病率显著相关。
