Division of Geriatric Medicine, Department of internal Medicine, Keio University School of Medicine, Tokyo, Japan.
J Nutr Health Aging. 2013 Jan;17(1):82-9. doi: 10.1007/s12603-012-0389-1.
To examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability.
A cross-sectional study.
A community-based survey conducted at university research center or home-based.
Four hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan.
Habitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the timed up and go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-α) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis. Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference.
Moderate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman's r=0.29-0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95% CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33-0.91), 0.88 (0.59-1.32), men and women respectively).
Habitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.
研究习惯性摄入海洋源 n-3 多不饱和脂肪酸（MOPUFA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）是否与社区中身体残疾高风险的 85 岁及以上老年人的功能性移动能力相关。
横断面研究。
在大学研究中心或基于家庭的社区进行的基于社区的调查。
日本中部社区中年龄最大的老年人的全健康东京老年人纵向研究的基线检查中，共有 542 名参与者，其中 417 名（189 名男性，228 名女性）。
通过简短型自我管理饮食史问卷（BDHQ）评估 MOPUFA 的习惯性饮食摄入，通过计时起立行走测试评估功能性移动能力。测量了血浆炎症生物标志物（C 反应蛋白、白细胞介素-6 和肿瘤坏死因子-α）。我们使用多变量逻辑回归分析评估了 MOPUFA 习惯性摄入与功能性移动能力之间的横断面关联。在分析之前，通过对 190 名参与者（96 名男性，94 名女性）的 BDHQ 进行验证，基于红细胞膜磷脂中 EPA 和 DHA 的浓度作为参考，确认了该研究中 BDHQ 的有效性。
从估计的饮食 EPA/DHA 摄入量和红细胞膜磷脂中 EPA/DHA 浓度之间获得了中度相关性（Spearman's r=0.29-0.58，p<0.01）。多变量逻辑回归分析显示，男性习惯性 EPA+DHA 摄入量较低与功能性移动能力较差显著相关，但女性则不然（EPA+DHA 摄入量每增加 1 SD 的比值比（95%CI）；男性 0.55（0.33-0.91），女性 0.88（0.59-1.32））。
习惯性 MOPUFA 摄入与社区居住的 85 岁及以上男性的功能性移动能力相关。
