Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan.
Antimicrob Agents Chemother. 2010 May;54(5):2239-43. doi: 10.1128/AAC.01677-09. Epub 2010 Mar 8.
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps in Escherichia coli.
NlpE，一种外膜脂蛋白，在革兰氏阴性菌的包膜应激反应中发挥作用。在本研究中，我们报告称，在大肠杆菌中，NlpE 的过表达通过激活编码 AcrD 和 MdtABC 多药外排泵的基因来增加多药和铜的耐药性。
