Molecular Biology Department, IICS, National University of Asuncion, Río de Plata y Lagerenza, 2511 Asunción, Paraguay.
Arch Virol. 2010 Apr;155(4):525-33. doi: 10.1007/s00705-010-0617-0. Epub 2010 Mar 7.
Rotavirus is the most common cause of severe diarrhea in children worldwide. Monitoring the diversity of rotavirus strains is of great importance for current and future vaccination programs. To determine the diversity of rotavirus circulating in Asuncion, Paraguay, between 2006 and 2007, we carried out a molecular characterization of rotaviruses detected in children <5 years old and adults (>18 years old). We found that the most common circulating strain was G2P[4] (69/143), followed by G9P[8] (37/143). The temporal distribution of strains showed that, in children, G2P[4] was predominant in 2006, and that G2P[4] and G9P[8] were co-predominant in 2007, whereas in adults, G2P[4] was predominant in both years. Additionally, one G9P[6] and three G12P[9] strains were found in adult samples, making this the first report of these strains circulating in Paraguay. Sequence analysis of the G12P[9] strains suggests across-border migration of this strain within the southern cone of America.
轮状病毒是全世界导致儿童严重腹泻的最常见原因。监测轮状病毒株的多样性对于当前和未来的疫苗接种计划非常重要。为了确定 2006 年至 2007 年间在巴拉圭亚松森流行的轮状病毒的多样性，我们对<5 岁儿童和>18 岁成人中检测到的轮状病毒进行了分子特征分析。我们发现最常见的流行株是 G2P[4]（69/143），其次是 G9P[8]（37/143）。菌株的时间分布表明，在儿童中，G2P[4]在 2006 年占优势，而在 2007 年 G2P[4]和 G9P[8]共同占优势，而在成人中，G2P[4]在这两年都占优势。此外，在成人样本中还发现了一株 G9P[6]和三株 G12P[9]株，这是这些株在巴拉圭流行的首次报告。对 G12P[9]株的序列分析表明，该株在南美南部锥体范围内发生了跨境迁移。
