.Autism Centre for Young Children, Handicap and Habilitation, Stockholm, Sweden.Unit of Developmental Disorders, Department of Paediatrics, and FoU centre, Skaraborg Hospital, Sweden.PRIMA Child and Adolescent Psychiatry, Stockholm, Sweden.Department of Paediatrics, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.Institute of Neuroscience and Physiology, Child and Adolescent Psychiatry, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Department of Molecular Medicine and Surgery, Karolinska Institute, and Karolinska University Hospital, Stockholm, Sweden.Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.
Acta Paediatr. 2010 May;99(5):743-747. doi: 10.1111/j.1651-2227.2010.01755.x. Epub 2010 Mar 5.
To analyse serum levels of 25-hydroxyvitamin D in mothers of Somali origin and those of Swedish origin who have children with and without autism as there is a growing evidence that low vitamin D impacts adversely on brain development.
Four groups of mothers were invited to participate; 20 with Somali origin with at least one child with autism, 20 with Somali origin without a child with autism, 20 of Swedish origin with at least one child with autism and 20 with Swedish origin without a child with autism. Two blood samples were collected from each individual; during autumn and spring.
Between 12 and 17 mothers from the different groups accepted to participate, both groups of mothers of Somali origin had significantly lower values of 25-hydroxyvitamin D compared with Swedish mothers. The difference of 25-hydroxyvitamin D between mothers of Somali origin with and without a child with autism was not significant.
Our findings of low vitamin D levels in Somali women entail considerable consequences in a public health perspective. The observed tendency, i.e. the lowest values in mothers of Somali origin with a child with autism was in the predicted direction, supporting the need for further research of vitamin D levels in larger samples of Somali mothers of children with and without autism.
分析来自索马里和瑞典的自闭症儿童母亲的血清 25-羟维生素 D 水平，因为越来越多的证据表明维生素 D 水平低会对大脑发育产生不利影响。
邀请了四组母亲参与研究；20 名来自索马里的母亲至少有一个自闭症儿童，20 名来自索马里的母亲没有自闭症儿童，20 名来自瑞典的母亲至少有一个自闭症儿童，20 名来自瑞典的母亲没有自闭症儿童。从每个个体中采集了两份血样；分别在秋季和春季采集。
不同组别的母亲中，有 12 到 17 位母亲接受了参与，来自索马里的两组母亲的 25-羟维生素 D 值明显低于瑞典母亲。来自索马里的有自闭症儿童和没有自闭症儿童的母亲之间的 25-羟维生素 D 差异没有统计学意义。
我们发现索马里妇女维生素 D 水平低，这在公共卫生角度具有重要意义。观察到的趋势，即有自闭症儿童的索马里裔母亲的维生素 D 值最低，与预期方向一致，这支持了在更大的自闭症和非自闭症儿童的索马里裔母亲样本中进一步研究维生素 D 水平的必要性。
