Bondeson L, Bengtsson A, Bondeson A G, Dahlenfors R, Grimelius L, Wedell B, Mark J
Laboratory of Cytology, Central Hospital, Skövde, Sweden.
Cancer. 1989 Aug 1;64(3):680-5. doi: 10.1002/1097-0142(19890801)64:3<680::aid-cncr2820640319>3.0.co;2-i.
Cytogenetic studies in thyroid neoplasia were performed by G-banding of chromosome preparations obtained from the in vitro cultures of nine adenomas, one follicular carcinoma, five papillary carcinomas, and two medullary carcinomas. Complex structural chromosome aberrations were found in one adenoma. Two more adenomas, both composed of Hürthle cells, showed multiple numerical chromosome deviations with trisomy 4 and tetrasomy 7 in common. Six metastasizing carcinomas were characterized by normal stemlines, which indicates that malignancy in thyroid neoplasia cannot be excluded by cytogenetic techniques used currently. Comparisons between cytogenetic findings and cytophotometric DNA measurements in the material studied illustrate that euploid tumors represent a heterogenous group including cases with various gross structural chromosome aberrations of yet unknown clinical significance. Further studies of additional material with long-term follow-up are called for by our findings of structural and numerical chromosome aberrations in follicular neoplasms that are benign according to histologic criteria.
对9例腺瘤、1例滤泡癌、5例乳头状癌和2例髓样癌的体外培养物进行染色体标本的G显带，以开展甲状腺肿瘤的细胞遗传学研究。在1例腺瘤中发现了复杂的结构染色体畸变。另外2例均由许特莱细胞构成的腺瘤显示出多个染色体数目偏差，常见的有4号染色体三体和7号染色体四体。6例转移性癌的特征是具有正常的干系，这表明目前使用的细胞遗传学技术不能排除甲状腺肿瘤中的恶性肿瘤。在所研究材料中细胞遗传学结果与细胞光度法DNA测量结果之间的比较表明，整倍体肿瘤代表一个异质性群体，包括具有各种临床意义尚不清楚的明显结构染色体畸变的病例。根据组织学标准为良性的滤泡性肿瘤中存在结构和数目染色体畸变，我们的这一发现表明需要对更多材料进行长期随访的进一步研究。
