RTI International,, Substance Abuse Treatment Evaluations and Interventions, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194 USA.
Drug Alcohol Depend. 2010 Jun 1;109(1-3):205-12. doi: 10.1016/j.drugalcdep.2010.01.014. Epub 2010 Mar 12.
HIV prevention intervention efficacy is often assessed in the short term. Thus, we conducted a long-term (mean 4.4 years) follow-up of a woman-focused HIV intervention for African American crack smokers, for which we had previously observed beneficial short-term gains.
455 out-of-treatment African American women in central North Carolina participated in a randomized field experiment and were followed up to determine sustainability of intervention effects across three conditions: the woman-focused intervention, a modified NIDA intervention, and a delayed-treatment control condition. We compared these groups in terms of HIV risk behavior at short-term follow-up (STFU; 3-6 months) and long-term follow-up (LTFU; average 4 years).
The analyses revealed two distinct groups at STFU: women who either eliminated or greatly reduced their risk behaviors (low-risk class) and women who retained high levels of risk across multiple risk domains (high-risk class). At STFU, women in the woman-focused intervention were more likely to be in the low HIV risk group than the women in control conditions, but this effect was not statistically significant at LTFU. However, low-risk participants at STFU were less likely to be retained at LTFU, and this retention rate was lowest among women in the woman-focused intervention.
Short-term intervention effects were not observed over 4 years later, possibly due to differential retention across conditions. The retention of the highest risk women presents an opportunity to extend intervention effects through booster sessions for these women.
艾滋病毒预防干预的效果通常在短期内进行评估。因此,我们对一项针对非裔美国女性 crack 吸食者的以女性为重点的艾滋病毒干预措施进行了长期(平均 4.4 年)随访,我们之前曾观察到该措施在短期取得了有益的效果。
北卡罗来纳州中部的 455 名非裔美国女性在治疗之外参与了一项随机现场实验,并进行了随访,以确定三种条件下干预效果的可持续性:以女性为重点的干预、修改后的 NIDA 干预和延迟治疗对照条件。我们比较了这些组在短期随访(STFU;3-6 个月)和长期随访(LTFU;平均 4 年)时的艾滋病毒风险行为。
分析显示,STFU 时有两个不同的群体:要么消除要么大大减少风险行为的女性(低风险类)和在多个风险领域保留高风险的女性(高风险类)。在 STFU 时,与对照组的女性相比,参与以女性为重点的干预的女性更有可能处于低艾滋病毒风险组,但这一效果在 LTFU 时并不显著。然而,STFU 时处于低风险的参与者在 LTFU 时更不可能被保留,而这一保留率在以女性为重点的干预组中最低。
4 年后没有观察到短期干预效果,这可能是由于不同条件下的保留率不同。保留最高风险的女性为这些女性提供了通过强化课程延长干预效果的机会。