Filipovský J, Simon J, Chrástek J, Rosolová H, Haman P, Petríková V
2nd Department of Internal Medicine, Medical Faculty, Charles University, Plzen, Czechoslovakia.
Cardiology. 1991;78(1):31-8. doi: 10.1159/000174762.
Among 77 hypertensive subjects with a previous predominantly sedentary way of life we followed the changes of several cardiovascular and biochemical parameters during a 5-week physical training course. A highly significant drop in both systolic and diastolic blood pressure (BP) was observed in 58 subjects (75%, p less than 0.001). There was a strong negative correlation between initial uricaemia and the diastolic BP decrease (r = -0.382; p less than 0.001). The decrease of systolic as well as diastolic BP correlated positively with the increase of maximum oxygen uptake per kilogram (VO2max/kg) during the intervention (for systolic BP: r = 0.282, p less than 0.05; for diastolic BP: r = 0.286, p less than 0.05). Serum total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), uricaemia levels and body mass index (BMI) decreased (p less than 0.01 for uricaemia; p less than 0.001 for the rest), whereas the HDL-C/TC ratio increased significantly (p less than 0.001). These positive changes disappeared already 3-7 months after the intervention except for BMI, TG and uricemia, where the lower levels persisted. Thus, the 5-week intensive physical training had a favourable but short-time effect on BP and lipid pattern in the majority of hypertensives.
在77名之前主要久坐不动的高血压患者中，我们追踪了他们在为期5周的体育训练课程中多项心血管和生化参数的变化。58名受试者（75%，p<0.001）的收缩压和舒张压均出现了极显著下降。初始尿酸血症与舒张压下降之间存在强烈的负相关（r = -0.382；p<0.001）。在干预期间，收缩压和舒张压的下降与每千克最大摄氧量（VO2max/kg）的增加呈正相关（收缩压：r = 0.282，p<0.05；舒张压：r = 0.286，p<0.05）。血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、尿酸血症水平和体重指数（BMI）均下降（尿酸血症p<0.01；其余p<0.001），而HDL-C/TC比值显著升高（p<0.001）。除BMI、TG和尿酸血症外，这些积极变化在干预后3至7个月就已消失，其中较低水平持续存在。因此，为期5周的强化体育训练对大多数高血压患者的血压和血脂模式有有利但短期的影响。
